A quantitative analysis of local anaesthetic alteration of miniature end-plate currents and end-plate current fluctuations.
نویسندگان
چکیده
منابع مشابه
Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.
1. Acetylcholine produced end-plate current (e.p.c.) noise is shown to be the results of statistical fluctuations in the ionic conductance of voltage clamped end-plates of Rana pipiens.2. These e.p.c. fluctuations are characterized by their e.p.c. spectra which conform to a relation predicted from a simple model of end-plate channel gating behaviour.3. The rate constant of channel closing alpha...
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The effects of neuromuscular blocking concentrations of hexamethomum and decamethonium on end-plate current parameters have been studied in frog sartorius nervemuscle preparations. In the presence of either drug, hyperpolarization of the cell membrane reduces the peak amplitude of the end-plate current despite the increase in driving force. The effect is larger for hexamethonium than for decame...
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Thyroid hormones (THs), primarily 3,3',5-triiode-(L)-thyronine (T(3)), have been clearly established as natural inducers of apoptosis during metamorphosis of anuran embryos. We decided to use this phenomenon to test the hypothesis that, prior to genomic activation, T(3) has acute actions in the neuromuscular junction (NMJ) of the tail of amphibian embryos. We detected a dramatic increase in the...
متن کاملExperimental Study and Comparative Numerical Analysis of the Mechanical Behavior of Extended End-Plate Connections with End-Plate Stiffeners
To investigate the influence of end-plate stiffeners on the initial rotational stiffness of extended end-plate internal joints, an experimental program was carried out to investigate the rotational behavior of the joints. Two finite element methods (FEMs) were proposed using ABAQUS software. The stress distribution, plastic development, and deformation characteristics of extended end-plate join...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1977
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1977.sp011659